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KMID : 0603519970020010045
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Journal of Korean Association of Cancer Prevention
1997 Volume.2 No. 1 p.45 ~ p.52
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Preventive Effect of Korean Red Ginseng on Cancers in AIDS Patients
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Cho Young-Keol
Lee Hee-Jung
Hur Sook-Jin
Nam Jung-Hyun
Oh Won-Il
Maeng Sung-Ho
Shin Yung-Oh
Won Young-Ho
Kim Nung-Soo
Cho Goon-Jae
Nam Ki-Yeul
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Abstract
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We have treated 130 human immunodeficiency virus-1 (HIV-1) infected individuals with Korean red ginseng (RG) since late 1991. CD4+T cell and CD8+T cell counts using flow cytometry have been routinely measured nearly every to 3∼6 months. Other immunnological markers have been measured for them. This study was attempted to evaluate whether Korean red ginseng (RG) intake has positive effects on survival and the prevention of cancer in HIV-1 inflected individuals. Among total number of patients who were diagnosed with HIV-1 antibody positive by Dec. 31, 1992, 64 cases expired by Dec. 31, 1996. The patients were divided into two groups, those with the intake of RG (n=21) and those without it (n=43), and the incidence of cancer was compared between the two groups. Data on cancer were collected via medical records. The duration of RG intake in 21 patients was 13.4±10.6 months (range. 3∼44; median, 11.5). The causes of death were AIDS (n=48), suicide (n=10), diseases other than AIDS (n=4), and accident (n=2). Cancers were confirmed in 8 (16.6%) of 48 who were expired by AIDS. Excluded 16 cases of death caused by diseases other than AIDS, the cancer incidence between two groups with RG intake and without it showed significant difference; 5.0% (1/20) versus 25.0% (7/28), respectively (Relative risk, 0.20; P<0.01). These results, as nationwide data, suggest that long-term intake of RG may have a preventive effect on cancers in AIDS patients.
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KEYWORD
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Cancer, AIDS, Korean red ginseng, CD4, T cell
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